RecruitingNot a traditional drug phaseinterventionalRules rewrite

Not a traditional drug phase: Cognitive Processing Therapy for PTSD - Post Traumatic Stress Disorder

This study will look at: How practical it is to offer another round of proven therapy. How effective different therapy options are for people who didn't respond to the first treatment.

Official registry: https://clinicaltrials.gov/study/NCT06733376 · Rush University Medical Center · enrollment listed as 400

What this phase means

This study does not use the classic phase 1–4 drug ladder. It may be a device, a behavior program, a surgery timing study, or an early feasibility test.

Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.

What the registry says happens

If you join, the listed intervention(s) are Cognitive Processing Therapy, Prolonged Exposure, or Skills Training for Affective and Interpersonal Regulation. The registry lists allocation as randomized. This study will look at: How practical it is to offer another round of proven therapy.

They plan to enroll about 400 people at Chicago. Taking part typically means following a program (exercise, therapy, diet, or an app) plus check-ins.

Official title (unrewritten)

Evaluating Evidence Based Options for Initial PTSD Treatment Non-Responders

Interventions: Cognitive Processing Therapy, Prolonged Exposure, Skills Training for Affective and Interpersonal Regulation

Primary outcome (registry wording): PTSD Checklist for DSM-5 (PCL-5)

Who it is for (from inclusion criteria)

Ages 18 Years to any
Are 18 years or older
Are fluent in English
Have experienced a Criterion A traumatic event during their lifetime
Have a PTSD diagnosis verified via the Clinician Administered PTSD Scale for DSM-5
Are interested in receiving evidence-based treatment for PTSD and able to attend 10 therapy sessions over the course of 2 weeks (10 days) and could possibly attend another 10 sessions of a subsequent treatment (additional CPT sessions, PE, or STAIR)
Are willing and able to complete self-report measures and clinician-rated assessments at multiple timepoints over the course of the study

Who the registry excludes

The index traumatic event occurred in the past month
They are currently suicidal or homicidal (i.e., current plan and imminent intent)
They have unmanaged psychosis or mania
They have not been on a stable dose of psychotropic medication for at least one month at the time of the baseline assessment
They have completed an evidence-based cognitive behavioral PTSD treatment in the past three months or are currently engaged in an evidence-based PTSD treatment (CPT, PE)
They have an intellectual disability or significant cognitive impairment that would prevent them from engaging in treatment
They have a serious or unstable medical illness or instability for which hospitalization may be likely within the next year

Public study contact (from the registry)

Philip Held, PhD

312-942-1423

philip_held@rush.edu

Published on ClinicalTrials.gov. Contact them as a possible participant. They decide eligibility.

Sites listed on ClinicalTrials.gov

1 listed

Rush University Medical Center — Chicago, Illinois (recruiting)

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FAQ about this NCT record

Is NCT06733376 still recruiting?

The sponsor posted status “Recruiting” on ClinicalTrials.gov at last ingest. Sites can pause independently. Confirm with the official record and the listed contact.

What phase is NCT06733376?

Not a traditional drug phase. Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.

Can PlainTrials tell me if I qualify for NCT06733376?

No. The inclusion and exclusion lists on this page are readable extracts of the public eligibility block. Only the study team can screen you.

How to read a ClinicalTrials.gov record · Questions to ask the coordinator · Glossary