PTSD trials combine psychotherapy, medicines, devices, or (in some records) psychedelic-assisted therapy under a protocol. Trauma type, CAPS scores, and current medicines often appear in inclusion text. We do not provide crisis care; use local emergency services if you are in danger. Sourced from ClinicalTrials.gov. Not a recommendation to join any study.
RecruitingNot a traditional drug phaseChicago, Illinois
Not a traditional drug phase: real iTBS for Mild Traumatic Brain InjuryThis study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation (iTBS), a type of repetitive transcranial magnetic stimulation and (ii) determine how APT + iTBS changes the neurocognitive system of attention in individuals with persistent attention deficits related to mTBI +/- PTSD.
NCT03819608 · Official ClinicalTrials.gov record · Northwestern University
RecruitingNot a traditional drug phaseLondon, Ontario
Not a traditional drug phase: Deep Brain Reorienting (DBR) for PTSDThis study will measure the how well it works of a therapeutic treatment, Deep Brain Reorienting (DBR), for PTSD (Post-traumatic Stress Disorder). you would be randomly assigned to either the DBR treatment, or wait-list condition.
NCT04317820 · Official ClinicalTrials.gov record · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
RecruitingNot a traditional drug phaseRichmond, Virginia
Not a traditional drug phase: Antioxidant for Peripheral Vascular DiseasesThe purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and/or generalized anxiety disorder (GAD)).
NCT04916327 · Official ClinicalTrials.gov record · Virginia Commonwealth University
RecruitingNot a traditional drug phaseLos Angeles, California
Not a traditional drug phase: Deep Brain Stimulation for FearAnxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. this study wants to understand the brain mechanisms that produce fear and anxiety in humans.
NCT05120635 · Official ClinicalTrials.gov record · Duke University
RecruitingNot a traditional drug phaseSan Diego, California
Not a traditional drug phase: Positive Airway Pressure Device for Post Traumatic Stress DisorderSubstance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in residential settings where both disorders are more severe than outpatient settings.
NCT05156112 · Official ClinicalTrials.gov record · VA Office of Research and Development
RecruitingPhase 2Afula
Phase 2: testing methylenedioxymethamphetamine for Post Traumatic Stress DisorderThe overall objective of this study is to use standard clinical measures to explore the safety and preliminary effectiveness of open-label MDMA-assisted therapy with a flexible dose of methylenedioxymethamphetaminel, in participants with war-related Post traumatic Stress Disorder, in a hybrid individual and group treatment protocol. The overall safety objective is to assess the severity, incidence, and frequency of AEs, AEs of Special Interest (AESIs), and Serious side effects (SAEs), concomitant medication use, suicidal ideation and behavior and vital signs .
NCT05732155 · Official ClinicalTrials.gov record · Guy Schusheim
RecruitingPhase 1New Haven, Connecticut
Phase 1: testing Ketamine for Depressive Disorder, MajorThe proposed study will assess the combined effect of perampanel and ketamine on the anti-depressant response in individuals with treatment resistant depression. this study wants to test the hypothesis that stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid receptors (AMPAR) is critical to the anti-depressant response of ketamine.
NCT05915013 · Official ClinicalTrials.gov record · Yale University
RecruitingNot a traditional drug phaseLexington, Kentucky
Not a traditional drug phase: Moderate Intensity Exercise for PTSDThe goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions.
NCT06127342 · Official ClinicalTrials.gov record · Christal L Badour
RecruitingNot a traditional drug phaseDallas, Texas
Not a traditional drug phase: Treatment as Usual for Traumatic InjuryThe purpose of this research is to determine if a brief treatment method is effective for preventing posttraumatic stress disorder (PTSD) and a number of other concerns following injury.
NCT06210711 · Official ClinicalTrials.gov record · Baylor Research Institute
RecruitingNot a traditional drug phaseEl Paso, Texas
Not a traditional drug phase: Parenting-STAIR Modular (PSTAIR-M) for PTSDThe goal of this study is to assess Parenting STAIR Modular (PSTAIR-M), a promising and innovative intervention for military-connected mothers (MCM) who have experienced trauma and their young children (ages 2-10). PSTAIR-M aims to help mothers manage the strong feelings that sometimes happen after experiencing something scary or stressful, as well as to better connect with their children and manage their behavior effectively.
NCT06262178 · Official ClinicalTrials.gov record · New York University
RecruitingPhase 3Jerusalem, Jerusalem
Phase 3: testing MDMA-AT for PTSD, Post Traumatic Stress DisorderDespite being exposed to a high level of potentially traumatic experiences due to exposure to combat, military veterans have poor response rates to traditional PTSD treatments, in some reports, just 1/3 of veterans recover using traditional treatments. In recent years 3,4-methylenedioxymethamphetamine (MDMA), a psychedelic drug has demonstrated a significant treatment potential for severe and treatment resistant PTSD though not specifically in a veteran population.
NCT06394284 · Official ClinicalTrials.gov record · Herzog Hospital
RecruitingPhase 1New Haven, Connecticut
Phase 1: testing Psilocybin for TransdiagnosticThe primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms. The secondary objective of this study is to determine whether individuals with functional impairments due to psychiatric symptoms will experience statistically significant symptom reduction and functional improvement from baseline symptom measurements (Visit 3) to 1-week (Visit 7), 4-weeks (Visit 8), and 6-weeks (Visit 9) post dosing.
NCT06442423 · Official ClinicalTrials.gov record · Yale University
RecruitingNot a traditional drug phaseAtlanta, Georgia
Not a traditional drug phase: Culturally Responsive SBIRT for OB for Pregnancy EarlyThis study will compare the effectiveness of two active screening interventions in improving post-traumatic stress disorder (PTSD) symptoms, maternal perinatal care utilization, satisfaction utilization of mental healthcare services, and maternal health and birth-related outcomes for Black pregnant women.
NCT06522022 · Official ClinicalTrials.gov record · Emory University
RecruitingPhase 2Birmingham, Alabama
Phase 2: testing Cyclobenzaprine HCl for Acute Stress ReactionThis study will examine the safety and how well it works of TNX-102 SL to reduce ASR symptoms and behavioral changes among patients presenting to the emergency department (ED) after motor vehicle collision (MVC). Specifically, the investigators will perform the Optimizing Acute Stress reaction Interventions with TNX-102 SL (OASIS) Trial, a neither you nor the study doctors know who gets the real treatment compared with a dummy treatment randomly assigned clinical trial (RCT) to determine if TNX-102 SL initiated in the ED in the hours after MVC to high risk individuals, treats/reduces acute stress reaction (ASR)/acute stress disorder (ASD) symptoms (primary outcome), improves neurocognitive function, and prevents/reduces posttraumatic stress (PTS) symptoms (secondary outcomes) long term.
NCT06636786 · Official ClinicalTrials.gov record · University of North Carolina, Chapel Hill
RecruitingPhase 2Los Angeles, California
Phase 2: testing Suvorexant for Alcohol Use Disorder (AUD)This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD). All participants will have a 7-day dummy treatment (placebo) run-in period, followed by a random assignment to receive dummy treatment (placebo) or suvorexant for an additonal 14 days.
NCT06679062 · Official ClinicalTrials.gov record · Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
RecruitingNot a traditional drug phaseChicago, Illinois
Not a traditional drug phase: Cognitive Processing Therapy for PTSD - Post Traumatic Stress DisorderThis study will look at: How practical it is to offer another round of proven therapy. How effective different therapy options are for people who didn't respond to the first treatment.
NCT06733376 · Official ClinicalTrials.gov record · Rush University Medical Center
RecruitingPhase 4San Francisco, California
Phase 4: testing Suvorexant for InsomniaPTSD affects approximately 22% of Veterans who have served in Iraq and Afghanistan. Symptoms of PTSD may include re-experiencing, avoidance of trauma reminders, negative thoughts or feelings, and hyperarousal, such as increased startle reactivity and disturbed sleep.
NCT06788522 · Official ClinicalTrials.gov record · VA Office of Research and Development
RecruitingNot a traditional drug phaseAurora, Colorado
Not a traditional drug phase: NightWare for Post Traumatic Stress DisorderThis study wants to determine whether NightWare therapeutic intervention improves biomarkers of vascular and renal function in premenopausal women with PTSD-related nightmares, and examine whether these improvements restore them to levels observed in age-matched women without PTSD.
NCT07021014 · Official ClinicalTrials.gov record · University of Colorado, Denver
RecruitingPhase 2Columbus, Ohio
Phase 2: Psilocybin + MBCT therapy for Post Traumatic Stress DisorderThe goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD). This is an assessor-blinded, randomly assigned, controlled study in participants with PTSD.
NCT07104916 · Official ClinicalTrials.gov record · Anthony P King
RecruitingNot a traditional drug phaseDetroit, Michigan
Not a traditional drug phase: Cognitive Behavioral Therapy for Insomnia for InsomniaThe goal of this randomly assigned controlled trial is to pilot the virtual delivery of cognitive behavioral therapy for insomnia (CBT-I) and nightmares (CBT-I\&N) via telehealth as an early intervention for treating posttraumatic sleep disturbance in acute trauma patients exposed to interpersonal violence. Test the acceptability, feasibility, and satisfaction of sleep-focused CBT delivered early after trauma 2.
NCT07121270 · Official ClinicalTrials.gov record · Henry Ford Health System
RecruitingPhase 2Atlanta, Georgia
Phase 2: testing psilocybin for PTSDThis pilot study will examine the safety, tolerability, acceptability, and how well it works of combination psilocybin + psychotherapy to decrease PTSD symptoms. you would be randomly assigned into two different treatment groups, allowing the investigators to directly compare PE augmented with psilocybin and psilocybin-assisted psychotherapy.
NCT07332143 · Official ClinicalTrials.gov record · Emory University
RecruitingNot a traditional drug phaseLittle Rock, Arkansas
Not a traditional drug phase: Written Exposure Therapy (WET) for Written Exposure TherapyThis study wants to examine two early interventions, Written Exposure Therapy and Capnometry Guided Breathing, to reduce post-traumatic stress disorder (PTSD) symptoms in women after childbirth as compared to usual care.
NCT07342530 · Official ClinicalTrials.gov record · Stanford University
RecruitingNot a traditional drug phaseStockholm
Not a traditional drug phase: Transdiagnostic metacognitive therapy for Generalized Anxiety DisorderThis is a qualitative study of participants who have taken part in a randomly assigned controlled trial comparing transdiagnostic metacognitive therapy and disorder-specific cognitive-behavioral therapy for anxiety disorders. The purpose of the study is to explore participant perceptions of the respective treatment models to facilitate implementation and dissemination of the treatments.
NCT07382323 · Official ClinicalTrials.gov record · Karolinska Institutet
RecruitingPhase 4Lexington, Kentucky
Phase 4: testing Dextrose 5% in water bilateral injection for PTSDPTSD is a chronic mental health condition that drastically reduces an individual's quality of life Dextrose injection with a small needle has been used for chronic pain patients and watch-and-measure (no experimental treatment required) results have shown it to be effective in reducing anxiety, brain fog, and depression in patients with PTSD. This randomly assigned trial will compare dextrose injection with an injection control of normal saline (NS)
NCT07382596 · Official ClinicalTrials.gov record · Dr. Dean Reeves Clinic
RecruitingNot a traditional drug phaseBeijing
Not a traditional drug phase: Mindfulness Intervention for Emotional Distress for Emotional DisordersThe goal of this clinical trial is to measure the effectiveness and cost-effectiveness of a digital mindfulness-based intervention in adults (aged 18-65) diagnosed with emotional disorders like depression or anxiety. The main questions it aims to answer are: * Does adding a digital mindfulness intervention to usual care help people recover from emotional disorders faster and more sustainably over two years?
NCT07458100 · Official ClinicalTrials.gov record · Peking University
RecruitingPhase 2 / Phase 3Tucson, Arizona
Phase 2 / Phase 3: testing COMP360 psilocybin for PTSD - Post Traumatic Stress DisorderThe Redefine Study (COMP202) is testing COMP360 to see if it may reduce post-traumatic stress disorder (PTSD) symptoms when administered alongside monitoring and support from a trained study team. COMP360 is a lab-made form of the naturally occurring chemical compound psilocybin.
NCT07570654 · Official ClinicalTrials.gov record · COMPASS Pathways
RecruitingNot a traditional drug phaseSan Antonio, Texas
Not a traditional drug phase: Live workshop for PTSD - Post Traumatic Stress DisorderThis research study tests strategies to train behavioral health providers in Written Exposure Therapy (WET), an evidence-based treatment for posttraumatic stress disorder (PTSD). There are a number of evidence-based treatments for posttraumatic stress disorder (PTSD).
NCT07707102 · Official ClinicalTrials.gov record · The University of Texas Health Science Center at San Antonio
RecruitingNot a traditional drug phaseWindisch, Canton of Aargau
Not a traditional drug phase: Trauma-Informed Parenting Group Intervention for Complex Post-Traumatic Stress DisorderThe goal of this pilot clinical trial is to learn whether NEST, a new trauma-informed group therapy program, is feasible and acceptable for parents with Complex PTSD, a condition that can develop after prolonged or repeated traumatic experiences. Parenting can be especially challenging for people with this condition, and few treatment programs currently address this specific need.
NCT07766265 · Official ClinicalTrials.gov record · St.Gallen University of Applied Sciences
RecruitingNot a traditional drug phaseXi'an, Shaanxi
Not a traditional drug phase: Unconscious Trauma Reactivation plus Eye Movements for Post-traumatic Stress Disorder (PTSD)Post-Traumatic Stress Disorder (PTSD) and trauma-related symptoms are often characterized by recurrent intrusive memories that cause distress and interfere with daily functioning. Although trauma-focused interventions such as Eye Movement Desensitization and Reprocessing (EMDR) may be effective, they often involve engagement with trauma-related memories, which can be distressing for some individuals and may affect treatment acceptability.
NCT07767396 · Official ClinicalTrials.gov record · Shaanxi Normal University
RecruitingPhase 3Denver, Colorado
Phase 3: testing TSND-201 for Post Traumatic Stress DisorderThis study is evaluating the safety and how well it works of TSND-201 in adults with PTSD. Eligible participants will enter a 4-week Treatment Period where they will be randomly assigned 1:1:1 to receive one of two doses of TSND-201 or dummy treatment (placebo), once per week.
NCT07836647 · Official ClinicalTrials.gov record · Transcend Therapeutics
RecruitingPhase 1Baltimore, Maryland
Phase 1: Virtual Reality for Traumatic Brain InjuriesThe primary goal of this study is to measure the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI. Specifically, the study will: Evaluate PTSD Symptom Reduction - PTSD symptoms, specifically hyperarousal and hypervigilance will be assessed using the Davidson Trauma Scale, which will provide insight into improvements PTSD symptom reduction.
NCT07890337 · Official ClinicalTrials.gov record · Johns Hopkins University
RecruitingNot a traditional drug phaseNewtownabbey, County Antrim
Not a traditional drug phase: VR Photoscan for PTSD - Post Traumatic Stress DisorderVirtual Reality (VR) is becoming an increasingly important tool in mental healthcare, offering new ways to enhance patient treatment. Over the past decade, there's been growing interest in using VR therapies because they create immersive, controlled environments tailored to individual therapeutic needs.
NCT07914634 · Official ClinicalTrials.gov record · Queen's University, Belfast