32 recruiting in this ClinicalTrials.gov snapshot · reviewed 2026-08-17
Osteoarthritis trials often focus on knee or hip pain, with X-ray grade and pain-score cutoffs. Injections, devices, medicines, and exercise programs all appear. A listed site is not a guarantee of insurance coverage or of benefit. Sourced from ClinicalTrials.gov. Not a recommendation to join any study.
Each headline is a rewrite of registry fields (phase, intervention, condition). Open the NCT link before you call a site. Eligibility is decided by the study team, not by this page. See how to find a trial and eligibility explained.
Phases in this snapshot: Not a traditional drug phase (24) · Phase 3 (4) · Phase 2 (3) · Phase 4 (1)
This study wants to determine the effect on hematological markers of nutritional intervention on nutritionally deficient patients following total joint replacement surgery.
NCT04210284 · Official ClinicalTrials.gov record · NYU Langone Health
Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern.
NCT04375280 · Official ClinicalTrials.gov record · University Hospital, Clermont-Ferrand
A multi-center randomly assigned compared with a dummy treatment clinical trial which determines the how well it works of trapeziectomy in patients with persistent painful osteoarthritis at the base of the thumb. The primary outcome is patient reported evaluation of pain and function of the wrist and hand at 6 months after the randomization to treatment group.
NCT05127005 · Official ClinicalTrials.gov record · Tampere University Hospital
To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis
NCT05559463 · Official ClinicalTrials.gov record · University of California, San Diego
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for clinical testing.
NCT05986292 · Official ClinicalTrials.gov record · Eli Lilly and Company
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites.
NCT06080347 · Official ClinicalTrials.gov record · University of California, San Diego
The EDUEX trial will determine whether the addition of progressive resistance training (PRT) to a patient education program (EDU) will improve clinical outcomes in patients with hip OA. In a subsample, the effect of PRT on the articular cartilage and other structures of the hip joint is investigated.
NCT06391554 · Official ClinicalTrials.gov record · University of Aarhus
The twofold goal of this study is to understand the link between muscle power, muscle strength, and muscle control degradation with the risk of falling, and to develop a framework for the comprehensive and quantitative assessment of muscle power (and strength) in an elderly population of patients with knee osteoarthritis, who are at higher risk of falling. The main question it aims to answer is: ● Are muscle power and motor control degradation better predictors of falls than muscle strength in the aging population?
NCT06611618 · Official ClinicalTrials.gov record · Istituto Ortopedico Rizzoli
The purpose of this research is to gather clinical and radiographic (X-ray) information about EMPHASYS™ acetabular shell (also called a hip 'cup') placement in total hip replacement surgery using a non-invasive surgical navigation system called VELYS™ hip navigation system with CUPTIMIZE™ Advanced Hip-Spine Analysis software. Data collected in this study will be compared with data collected from implantations using different cup positioning instrumentation and techniques to assess performance.
NCT06631638 · Official ClinicalTrials.gov record · DePuy Orthopaedics
Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot randomly assigned Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-related pain at 3 months as measured by the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscore. Additionally, this study aims to determine the magnitude of difference in pain response between GAE and sham to adequately power a larger, more definitive randomly assigned sham-controlled trial (RCT).
NCT06859164 · Official ClinicalTrials.gov record · University of Utah
The goal of this randomly assigned controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the treatment of cartilage defects of the distal femur in adult patients with knee pain and symptoms who are candidates for surgical intervention of the knee compared to outcomes for the control group. The primary effectiveness endpoint is Month 24 composite clinical success (CCS) defined by: * no secondary surgical intervention (SSI) and * an improvement from baseline in the Knee injury and Osteoarthritis Outcome Score (KOOS) total score (scaled 0 to 100) of at least 10 points.
NCT06915363 · Official ClinicalTrials.gov record · BioPoly LLC
This single-site, single-arm study evaluates the feasibility, safety, tolerability, and how well it works of trans-arterial embolization (TAE) using Embozene microparticles for treating facetogenic pain due to facet arthropathy (osteoarthritis of the facet joints) in the lumbar spine.
NCT06965452 · Official ClinicalTrials.gov record · Northwell Health
This study involves the use of sound waves to block pain signals caused by osteoarthritis of the knee. The sound waves are tightly focused on a specific area of the nerve.
NCT07178951 · Official ClinicalTrials.gov record · FUSMobile Inc.
The goal of this clinical trial is to evaluate whether different types of regional anesthesia can improve pain control and functional recovery after total hip arthroplasty in adult patients undergoing elective hip replacement surgery. The main questions it aims to answer are: Does the PENG block reduce opioid use in the first 48 hours after surgery more effectively than the combined L-ESPB + S-ESPB technique?
NCT07180979 · Official ClinicalTrials.gov record · Poznan University of Medical Sciences
This study will test whether CARTISTEM is safe and works better than debridement (a surgery that cleans out damaged tissue) for people with knee cartilage damage and osteoarthritis. CARTISTEM is a new treatment made of stem cells from donated umbilical cord blood mixed with a gel (hyaluronic acid) that is placed in the damaged area of the knee The main goal is to find out if CARTISTEM® reduces knee pain and improves knee function more than debridement two years after treatment.
NCT07339111 · Official ClinicalTrials.gov record · Medipost, Inc.
The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain.
NCT07353931 · Official ClinicalTrials.gov record · Eli Lilly and Company
The aim of our study is to measure the effects of graded motor imagery training applied in addition to a structured exercise program in individuals with foot and/or ankle osteoarthritis. The study population will consist of twenty-four individuals diagnosed with foot/ankle osteoarthritis who applied to the Orthopedics and Traumatology Department of Alanya Alaaddin Keykubat University Education and Research Hospital.
NCT07417436 · Official ClinicalTrials.gov record · Alanya Alaaddin Keykubat University
This randomly assigned controlled trial evaluates the effect of ultrasound-guided iPACK block with Adductor Canal Block (ACB) on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under spinal anesthesia. SII, calculated as platelet × neutrophil / lymphocyte count, is used as a composite marker of perioperative inflammatory and immune response.
NCT07449442 · Official ClinicalTrials.gov record · Poznan University of Medical Sciences
His study will test whether giving dexamethasone through a vein can improve pain control after total hip replacement surgery. Dexamethasone is commonly used to reduce nausea and may also help with pain, but it is not clear which dose works best.
NCT07581470 · Official ClinicalTrials.gov record · Poznan University of Medical Sciences
The goal of this clinical trial is to learn which of three regional anesthesia approaches provides better pain relief and safety for older adults having planned hip replacement surgery. Researchers will study people aged 60 years and older who are scheduled for elective total hip arthroplasty.
NCT07584200 · Official ClinicalTrials.gov record · Poznan University of Medical Sciences
The main purpose of this study is to test the safety and how well it works of study drug for the treatment of knee pain due to osteoarthritis (OA). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chronic pain.
NCT07641517 · Official ClinicalTrials.gov record · Eli Lilly and Company
This prospective randomly assigned controlled trial aims to compare the analgesic how well it works and safety of three adjuvant strategies for ultrasound-guided Adductor Canal Block (ACB) and iPACK block in patients undergoing elective total knee arthroplasty under spinal anesthesia. All participants will receive standardized spinal anesthesia with 0.5% ropivacaine combined with ACB and iPACK blocks using 0.2% ropivacaine.
NCT07677215 · Official ClinicalTrials.gov record · Poznan University of Medical Sciences
Surgical trauma induces activation of the sympathetic nervous system and triggers a systemic inflammatory response that may adversely affect postoperative recovery. Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has been proposed as a pharmacological neuromodulatory strategy capable of attenuating sympathetic activation and modulating neuroimmune interactions during the perioperative period.
NCT07743853 · Official ClinicalTrials.gov record · Poznan University of Medical Sciences
This study aims to compare the how well it works of unipolar versus bipolar radiofrequency ablation (RFA) in knee osteoarthritis pain.
NCT07789340 · Official ClinicalTrials.gov record · Tanta University
The goal of this watch-and-measure (no experimental treatment required), non-treatment cohort study is to identify tests or markers in blood or knee fluid, or any genetic risk factors that might contribute to worsening or improvement of knee osteoarthritis. Males and females aged ≥18 with early-stage knee osteoarthritis, prior proven acute knee injury, or degenerative meniscal tear will be recruited at Imperial College Healthcare NHS Trust.
NCT07833488 · Official ClinicalTrials.gov record · Imperial College London
Many patients feel anxious before joint replacement surgery. This anxiety is common - affecting roughly 1 in 3 patients - and research has shown that patients who are more anxious before surgery tend to have more pain afterward and may need more pain medication during recovery.
NCT07845695 · Official ClinicalTrials.gov record · Columbia University
This prospective watch-and-measure (no experimental treatment required) cohort study aims to investigate the association between preoperative multimorbidity burden and functional recovery after primary total knee arthroplasty (TKA) in patients with knee osteoarthritis. Approximately 230 adult patients undergoing elective unilateral primary TKA will be enrolled at a single hospital in Türkiye.
NCT07882316 · Official ClinicalTrials.gov record · Balikesir Ataturk City Hospital
The effect of aquatic exercise on central sensitization in patients with knee osteoarthritis are not fully known in the studies conducted to date. The aim of this study is to examine the effect of aquatic exercise on central sensitization and functional parameters in patients with knee osteoarthritis.
NCT07883824 · Official ClinicalTrials.gov record · Kirsehir Ahi Evran Universitesi
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity with and without type 2 diabetes. The study will last 52 weeks and compare the effects of berobenatide compared to dummy treatment (placebo) on knee pain, physical function, and body weight.
NCT07915609 · Official ClinicalTrials.gov record · Pfizer
To Evaluate Feasibility and Exploratory Clinical and Biomarker Signals of NRPT in Adults with Knee Osteoarthritis
NCT07917403 · Official ClinicalTrials.gov record · University of California, San Diego
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity. The study will last 52 weeks and compare the effects of berobenatide compared to dummy treatment (placebo) on knee pain, physical function, and body weight.
NCT07919678 · Official ClinicalTrials.gov record · Pfizer
Knee osteoarthritis (KOA) is a common musculoskeletal condition associated with pain, impaired physical function, and movement-related fear. Psychological factors, particularly fear of movement (kinesiophobia), may influence movement behavior and limit participation in physical activity and exercise therapy.
NCT07920120 · Official ClinicalTrials.gov record · University of Primorska
This hub lists 32 recruiting Osteoarthritis studies from a ClinicalTrials.gov snapshot, rewritten in plain English. Each card links to its NCT record. You can also search the official registry for “osteoarthritis” at https://clinicaltrials.gov/search?cond=osteoarthritis.
A phase explainer, a plain-English summary grounded in the brief summary, inclusion/exclusion extracted from the public eligibility block, sponsor name, and any central contact the sponsor published. It is not a match to a trial.
Sites that appear on these records include Chicago, Illinois; Miami, Florida; Poznan, Poland; Birmingham, Alabama; Phoenix, Arizona. A city on a record is not a guarantee that the site is taking new patients this week — call the NCT contact.
No. Eligibility is decided by the study team using the protocol, labs, and consent. Our “who it is for” list is a readable extract of public inclusion text only.
Biologics, JAK inhibitors, and tapering studies for people already on treatment.
B-cell and interferon-pathway drugs for SLE and lupus nephritis.
Injectable biologics, oral TYK2 drugs, and combination skin studies.
Gut-targeted biologics, oral drugs, and diet studies.
Gut-targeted biologics, oral small molecules, and combination induction studies.
Biologics, JAK inhibitors, and topical studies for eczema.