Not medical advice. This website is not medical advice, a diagnosis, a match to a trial, or a recommendation to join a study. Listings are plain-English rewrites of public ClinicalTrials.gov records. Whether a site is still enrolling, and whether you qualify, can only be confirmed by the study team and your clinician. Source registry: ClinicalTrials.gov. Editorial rules: methodology.
PlainTrials
RecruitingPhase 2interventionalRules rewrite

Phase 2: testing VERVE-102 for Atherosclerosis

This study wants to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to dummy treatment (placebo) in adults who have plaque buildup in their arteries or are at high risk of developing it.

Official registry: https://clinicaltrials.gov/study/NCT07839936 · Verve Therapeutics, Inc. · enrollment listed as 175

What this phase means

Phase 2: researchers already know a roughly safe dose (from phase 1). This stage asks whether the treatment actually helps the condition, and watches side effects more closely.

Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.

What the registry says happens

If you join, the listed intervention(s) are VERVE-102, or Placebo. The registry lists allocation as randomized. This study wants to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to dummy treatment (placebo) in adults who have plaque buildup in their arteries or are at high risk of developing it.

They plan to enroll about 175 people at DeSoto. Taking part typically means taking a study drug (or dummy pill) plus check-ins.

Official title (unrewritten)

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of VERVE-102, a One-Time Dose Gene Editing Medicine, in Adults With or at High Risk for Atherosclerotic Cardiovascular Disease (ASCVD) Who Require Additional Low-Density Lipoprotein-Cholesterol (LDL-C) Lowering

Interventions: VERVE-102, Placebo

Primary outcome (registry wording): Percent Change from Baseline in LDL-C

Who it is for (from inclusion criteria)

  • Ages 18 Years to 70 Years
  • Established atherosclerotic cardiovascular disease (ASCVD) and/or at a high risk of ASCVD

Public study contact (from the registry)

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

317-615-4559

LillyTrials@Lilly.com

Published on ClinicalTrials.gov. Contact them as a possible participant. They decide eligibility.

Sites listed on ClinicalTrials.gov

1 listed

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FAQ about this NCT record

Is NCT07839936 still recruiting?

The sponsor posted status “Recruiting” on ClinicalTrials.gov at last ingest. Sites can pause independently. Confirm with the official record and the listed contact.

What phase is NCT07839936?

Phase 2. Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.

Can PlainTrials tell me if I qualify for NCT07839936?

No. The inclusion and exclusion lists on this page are readable extracts of the public eligibility block. Only the study team can screen you.

How to read a ClinicalTrials.gov record · Questions to ask the coordinator · Glossary