Not medical advice. This website is not medical advice, a diagnosis, a match to a trial, or a recommendation to join a study. Listings are plain-English rewrites of public ClinicalTrials.gov records. Whether a site is still enrolling, and whether you qualify, can only be confirmed by the study team and your clinician. Source registry: ClinicalTrials.gov. Editorial rules: methodology.
PlainTrials
RecruitingPhase 2interventionalRules rewrite

Phase 2: testing VS-7375 for Pancreatic Ductal Adenocarcinoma (PDAC)

This study will assess the safety and how well it works of VS-7375 alone and in combination with cetuximab in patients with metastatic KRAS G12D - mutated Pancreatic Cancer

Official registry: https://clinicaltrials.gov/study/NCT07644559 · Verastem, Inc. · enrollment listed as 185

What this phase means

Phase 2: researchers already know a roughly safe dose (from phase 1). This stage asks whether the treatment actually helps the condition, and watches side effects more closely.

Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.

What the registry says happens

If you join, the listed intervention(s) are VS-7375, or cetuximab (or panitumumab if α-gal IgE+ or cetuximab reaction). The registry lists allocation as randomized. This study will assess the safety and how well it works of VS-7375 alone and in combination with cetuximab in patients with metastatic KRAS G12D - mutated Pancreatic Cancer

They plan to enroll about 185 people at 38 sites. Taking part typically means taking a study drug (or dummy pill) plus check-ins.

Official title (unrewritten)

A Phase 2, Open-label Study of VS-7375, an Oral KRAS G12D (ON/OFF) Inhibitor, as Monotherapy and With Cetuximab, in Patients With Metastatic KRAS G12D-Mutated Pancreatic Cancer (TARGET-D 201)

Interventions: VS-7375, cetuximab (or panitumumab if α-gal IgE+ or cetuximab reaction)

Primary outcome (registry wording): Confirmed ORR by blinded independent central review (BICR) per RESIST v1.1

Who it is for (from inclusion criteria)

  • Ages 18 Years to any
  • Histologic or cytologic confirmed PDAC
  • Measurable disease per RECIST 1.1
  • Local testing confirmed KRAS G12D mutation (tissue required for confirmatory central testing)
  • Adequate organ function
  • VS-7375 + cetuximab (2L PDAC) :
  • Received only 1 prior Tx in the metastatic setting; prior adjuvant counts as a line if progressed within 6 months
  • VS-7375 + cetuximab (1L PDAC) :

Public study contact (from the registry)

Verastem Call Center

7812924204

VS-7375-201TrialSupport@verastem.com

Published on ClinicalTrials.gov. Contact them as a possible participant. They decide eligibility.

Sites listed on ClinicalTrials.gov

38 listed

+ 11 sites outside the US on the same record

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NCT01174121 · Official ClinicalTrials.gov record · National Cancer Institute (NCI)

FAQ about this NCT record

Is NCT07644559 still recruiting?

The sponsor posted status “Recruiting” on ClinicalTrials.gov at last ingest. Sites can pause independently. Confirm with the official record and the listed contact.

What phase is NCT07644559?

Phase 2. Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.

Can PlainTrials tell me if I qualify for NCT07644559?

No. The inclusion and exclusion lists on this page are readable extracts of the public eligibility block. Only the study team can screen you.

How to read a ClinicalTrials.gov record · Questions to ask the coordinator · Glossary