Not medical advice. This website is not medical advice, a diagnosis, a match to a trial, or a recommendation to join a study. Listings are plain-English rewrites of public ClinicalTrials.gov records. Whether a site is still enrolling, and whether you qualify, can only be confirmed by the study team and your clinician. Source registry: ClinicalTrials.gov. Editorial rules: methodology.
RecruitingNot a traditional drug phaseinterventionalRules rewrite
Not a traditional drug phase: Inspiratory Muscle Strength Training High-Resistance for Systolic Blood Pressure
Using a 2-arm, RCT approach, the primary goal of the study is to measure the feasibility and preliminary how well it works of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine secondary effects of IMST on mood, sleep quality, systemic inflammation, and physical/motor function.
This study does not use the classic phase 1–4 drug ladder. It may be a device, a behavior program, a surgery timing study, or an early feasibility test.
Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.
What the registry says happens
If you join, the listed intervention(s) are Inspiratory Muscle Strength Training High-Resistance, or Inspiratory Muscle Strength Training Low-Resistance. The registry lists allocation as randomized. Using a 2-arm, RCT approach, the primary goal of the study is to measure the feasibility and preliminary how well it works of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults.
They plan to enroll about 30 people at Tallahassee. Taking part typically means using or being fitted with a device plus check-ins.
Official title (unrewritten)
Randomized Controlled Pilot Trial of Inspiratory Muscle Strength Training (IMST) to Reduce Dementia Risk in Older Adults
Interventions: Inspiratory Muscle Strength Training High-Resistance, Inspiratory Muscle Strength Training Low-Resistance
Primary outcome (registry wording): Change in systolic BP
Who it is for (from inclusion criteria)
Ages 60 Years to 80 Years
Converted telephone MoCA total score≥18
Capable of independently completing or requiring minimal assistance with inspiratory muscle strength training (IMST)
Willing to adhere to the IMST protocol (approximately 5-10 minutes per day for 8 weeks)
Optional inclusion of inspiratory muscle weakness (MIP \<80 cmH₂O for men, \<70 cmH₂O for women) will also be assessed
Who the registry excludes
tMoCA \<18, or diagnosis of neurodegenerative illness at the discretion of principal investigator (except MCI)
Current evidence of any major psychiatric disorder including psychosis (at the discretion of principal investigator), bipolar disorder, severe major depression (PHQ-9 \> 20)
Unstable cardiovascular or pulmonary disease
Recent respiratory therapy or major medication changes
Self-reported severe untreated or unstable obstructive sleep apnea (OSA)
Recent start (within the past month) of CPAP or BiPAP, or recent use of inspiratory muscle training
Lung and eardrum injuries
Contact
No central phone on the registry card. Use the official listing to reach a site.
Sites listed on ClinicalTrials.gov
1 listed
Florida State University — Tallahassee, Florida (recruiting)
Study Description: This study examines relations between neurocognitive and clinical features of pediatric anxiety disorders. The study uses neuro-cognitive tasks, functional magnetic resonance imaging (fMRI), as well as magneto- and electro-encephalography (M/EEG).
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies.
The specific aims of the study are: Primary: To determine the presence and regional distribution of microglial activation, as assessed by Fluorine-18 (18F) labeled "Peripheral Benzodiazepine Receptor 06" (PBR06) -PET, in subjects with active Relapsing Remitting Multiple Sclerosis (RRMS), Secondary Progressive Multiple Sclerosis (SPMS), and Alzheimer's Disease (AD) as compared to healthy controls Secondary: 1. To assess the relationship between microglial activation and clinical variables including disease severity and comorbidities (such as pain, fatigue and/or depression), as well as clinical MRI findings (such as lesions and atrophy) 2.
The sponsor posted status “Recruiting” on ClinicalTrials.gov at last ingest. Sites can pause independently. Confirm with the official record and the listed contact.
What phase is NCT07349706?
Not a traditional drug phase. Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.
Can PlainTrials tell me if I qualify for NCT07349706?
No. The inclusion and exclusion lists on this page are readable extracts of the public eligibility block. Only the study team can screen you.