Not medical advice. This website is not medical advice, a diagnosis, a match to a trial, or a recommendation to join a study. Listings are plain-English rewrites of public ClinicalTrials.gov records. Whether a site is still enrolling, and whether you qualify, can only be confirmed by the study team and your clinician. Source registry: ClinicalTrials.gov. Editorial rules: methodology.
PlainTrials
RecruitingPhase 2interventionalRules rewrite

Phase 2: testing Colchicine for Heart Failure With Preserved Ejection Fraction

This study will measure the impact of colchicine on the change in myocardial flow reserve (MFR), a marker for coronary microvascular dysfunction (CMD), compared to a matched dummy treatment (placebo) in patients with heart failure and ejection fraction above 40% (including patients with improved EF).

Official registry: https://clinicaltrials.gov/study/NCT06217120 · Montreal Heart Institute · enrollment listed as 64

What this phase means

Phase 2: researchers already know a roughly safe dose (from phase 1). This stage asks whether the treatment actually helps the condition, and watches side effects more closely.

Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.

What the registry says happens

If you join, the listed intervention(s) are Colchicine, or Placebo. The registry lists allocation as randomized. This study will measure the impact of colchicine on the change in myocardial flow reserve (MFR), a marker for coronary microvascular dysfunction (CMD), compared to a matched dummy treatment (placebo) in patients with heart failure and ejection fraction above 40% (including patients with improved EF).

They plan to enroll about 64 people at Montreal. Taking part typically means taking a study drug (or dummy pill) plus check-ins.

Official title (unrewritten)

Reversing Microvascular Dysfunction in Heart Failure With Ejection Fraction > 40% Using Colchicine (The COL-Micro-HF Study)

Interventions: Colchicine, Placebo

Primary outcome (registry wording): Change in myocardial flow reserve (MFR) between baseline and six months

Who it is for (from inclusion criteria)

  • Ages 40 Years to any
  • Subjects ≥ 40 years of age,
  • Chronic symptomatic HF and left ventricular ejection fraction (LVEF) \> 40% within 12 months prior to screening visit (regardless of the imaging modality) and one of the following abnormalities:

Contact

No central phone on the registry card. Use the official listing to reach a site.

Sites listed on ClinicalTrials.gov

1 listed

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FAQ about this NCT record

Is NCT06217120 still recruiting?

The sponsor posted status “Recruiting” on ClinicalTrials.gov at last ingest. Sites can pause independently. Confirm with the official record and the listed contact.

What phase is NCT06217120?

Phase 2. Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.

Can PlainTrials tell me if I qualify for NCT06217120?

No. The inclusion and exclusion lists on this page are readable extracts of the public eligibility block. Only the study team can screen you.

How to read a ClinicalTrials.gov record · Questions to ask the coordinator · Glossary