These studies list at least one location in Thessaloniki, Greece. A listed city is not a guarantee the site is still taking patients — call the contact.
RecruitingPhase 3Tucson, Arizona
Phase 3: testing Pembrolizumab for Solid TumorsThis study wants to measure the long-term safety and how well it works of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who transition into this extension study. This study will consist of three phases: 1) First Course Phase, 2) Survival Follow-up Phase or 3) Second Course Phase.
NCT03486873 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 2Huntsville, Alabama
Phase 2: testing Nivolumab for CancerMain Objective of this study is to examine long-term safety of nivolumab this drug alone including combinations and other cancer therapies in various tumor types.
NCT03899155 · Official ClinicalTrials.gov record · Bristol-Myers Squibb
RecruitingPhase 3CABA, Buenos Aires
Phase 3: testing QMF149 for AsthmaThis study wants to measure the superiority in terms of how well it works and measure the safety of QMF149 (indacaterol (acetate) / mometasone (furoate)) compared to budesonide in children from 6 to less than 12 years of age with asthma. * The study duration will be up to 37 weeks including an investigational treatment duration of 12 weeks and a comparator treatment duration of 12 weeks.
NCT05562466 · Official ClinicalTrials.gov record · Novartis Pharmaceuticals
RecruitingPhase 3Santa Barbara, California
Phase 3: testing Sotorasib for Non-Small Cell Lung Cancer (NSCLC)The primary objectives are to compare progression-free survival (PFS) and overall survival (OS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants who receive pembrolizumab with platinum doublet chemotherapy.
NCT05920356 · Official ClinicalTrials.gov record · Amgen
RecruitingPhase 3Chandler, Arizona
Phase 3: testing FOLFIRI Regimen for Metastatic Colorectal CancerThe aim of this study is to compare progression free survival (PFS) in treatment-naïve participants with KRAS p.G12C mutated metastatic colorectal cancer (mCRC) receiving sotorasib, panitumumab and FOLFIRI vs FOLFIRI with or without bevacizumab-awwb.
NCT06252649 · Official ClinicalTrials.gov record · Amgen
RecruitingNot a traditional drug phaseBirmingham, Alabama
Not a traditional drug phase: Durvalumab-based combination therapies in observational study setting for Hepatobiliary CancersGiven the number of anticipated durvalumab-based treatment launches in the hepatobiliary cancer space over the next 3 years, there is a need to capture contemporary real-world data across these indications. LIVER-R is a multi-country, multi-center, watch-and-measure (no experimental treatment required) study of patients with a confirmed diagnosis of hepatobiliary cancer treated with or without a durvalumab-based regimen as part of routine clinical practice or early access program (EAP).
NCT06252753 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Alexander City, Alabama
Phase 3: testing balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg for Heart Failure and Impaired Kidney FunctionThis is a Phase III, international, multi-centre, randomly assigned, neither you nor the study doctors know who gets the real treatment, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is to measure the effect of balcinrenone/dapagliflozin vs dapagliflozin, given once daily on top of other classes of SoC, on CV death and HF events.
NCT06307652 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Little Rock, Arkansas
Phase 3: testing Sacituzumab tirumotecan for Non Small Cell Lung CancerThis study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab this drug alone with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR).
NCT06312137 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Bakersfield, California
Phase 3: testing Calderasib for Non-small Cell Lung CancerThis is a study evaluating the how well it works and safety of calderasib with pembrolizumab as first-line treatment in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) with identified Kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation and programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) ≥50%. There is one primary study hypothesis: Combination of calderasib and pembrolizumab is superior to dummy treatment (placebo) plus pembrolizumab with respect to progression free survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) by blinded independent central review (BICR).
NCT06345729 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Dothan, Alabama
Phase 3: testing IV Tulisokibart for Crohn's DiseaseThe purpose of this protocol is to measure the how well it works and safety of tulisokibart in participants with moderately to severely active Crohn's disease. Study 1's primary hypotheses are that at least 1 tulisokibart dose level is superior to dummy treatment (placebo) in the proportion of participants achieving clinical remission per Crohn's Disease Activity Index score (\<150, US/FDA) or per stool frequency and abdominal pain score (EU/EMA) and in the proportion of participants achieving endoscopic response at Week 52 (US/FDA and EU/EMA), and that at least 1 tulisokibart dose level is superior to dummy treatment (placebo) in the proportion of participants achieving clinical remission per Crohn's Disease Activity Index score (\<150, US/FDA) or per stool frequency and abdominal pain score (EU/EMA) and in the proportion of participants achieving endoscopic response at Week 12 (US/FDA and EU/EMA).
NCT06430801 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingNot a traditional drug phaseAthens, Attica
Not a traditional drug phase: Ofatumumab for Relapsing Multiple Sclerosis (RMS)This study is a single-country, non-treatment, multicenter, watch-and-measure (no experimental treatment required) study, mainly based on primary data collection to assess the effect of ofatumumab on clinical parameters of Multiple Sclerosis (MS) in a routine medical care setting, as compared to the standard of care (SoC) arm of a closely monitored phase-IIIb study (STHENOS, which includes glatiramer acetate, interferons, teriflunomide, or dimethyl fumarate)
NCT06486779 · Official ClinicalTrials.gov record · Novartis Pharmaceuticals
RecruitingPhase 3Chandler, Arizona
Phase 3: testing KarXT for Alzheimer DiseaseThis study wants to measure the safety and how well it works of KarXT in adult participants with mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD.
NCT06585787 · Official ClinicalTrials.gov record · Karuna Therapeutics, Inc., a Bristol Myers Squibb company
RecruitingPhase 1 / Phase 2Scottsdale, Arizona
Phase 1 / Phase 2: testing XmAb942 for Ulcerative Colitis (UC)The Phase 1 study described herein will measure the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb942 in healthy volunteers (Parts A and B). Part C of this study will be a Phase 2 study to evaluate XmAb942 in participants with ulcerative colitis (UC).
NCT06619990 · Official ClinicalTrials.gov record · Xencor, Inc.
RecruitingPhase 3Gilbert, Arizona
Phase 3: testing Pembrolizumab for Carcinoma, Non-Small-Cell LungThe goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive dummy treatment (placebo) and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).
NCT06623422 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Daphne, Alabama
Phase 3: testing BMS-986489 (Atigotatug+Nivolumab) for Extensive-Stage Small Cell Lung CancerThe Purpose of the Study is to Compare the how well it works and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
NCT06646276 · Official ClinicalTrials.gov record · Bristol-Myers Squibb
RecruitingPhase 3Birmingham, Alabama
Phase 3: testing Baxdrostat and dapagliflozin for Heart FailureParticipants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screening period to facilitate sites' identification of potentially eligible participants to enter the full screening assessments.
NCT06677060 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Fairhope, Alabama
Phase 3: testing Baxdrostat/dapagliflozin for Chronic Kidney Disease and HypertensionInternational, Multicenter, neither you nor the study doctors know who gets the real treatment, compared with a dummy treatment and Event-driven study to assess how well it works, whether it is safe and how hard side effects are to live with of Baxdrostat in combination with Dapagliflozin on renal outcomes and cardiovascular mortality in participants with chronic kidney disease and high blood pressure
NCT06742723 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Jonesboro, Arkansas
Phase 3: testing Arm A: Gedatolisib + Palbociclib + Fulvestrant for Breast CancerThis is a Phase 3, open-label, randomly assigned, clinical trial evaluating the how well it works and safety of gedatolisib and palbociclib plus endocrine therapy for the treatment of patients with locally advanced or metastatic HR+/HER2- advanced breast cancer.
NCT06757634 · Official ClinicalTrials.gov record · Celcuity Inc
RecruitingNot a traditional drug phaseQuilmes, Buenos Aires
An Ex-US Study to Assess Treatment Persistence With Risankizumab in Adult Participants With Psoriatic Arthr…Psoriatic arthritis (PsA) is a type of arthritis (swelling and stiffness in the joints) that is frequently seen in trial participants who also have the skin condition psoriasis. It is caused by an overactive immune system where the body attacks healthy tissue by mistake.
NCT06764693 · Official ClinicalTrials.gov record · AbbVie
RecruitingPhase 3Birmingham, Alabama
Phase 3: testing CYB003 for Major Depressive Disorder (MDD)This study wants to determine the how well it works, whether it is safe and how hard side effects are to live with of CYB003 compared to matching dummy treatment (placebo) as added on top of your current treatment treatment in patients with major depression. For more information about the EMBRACE study, including participating study locations, and to register your interest in learning more about participation, please visit the study website: https://embrace-mdd-trial.com/
NCT06793397 · Official ClinicalTrials.gov record · Cybin IRL Limited
RecruitingPhase 3Burbank, California
Phase 3: testing Trastuzumab Deruxtecan for Ovarian CancerThis clinical trial is designed to measure the how well it works and safety of T-DXd in combination with bevacizumab versus bevacizumab this drug alone as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry \[IHC\] 3+/2+/1+) advanced high-grade epithelial ovarian cancer.
NCT06819007 · Official ClinicalTrials.gov record · Daiichi Sankyo
RecruitingPhase 3Mobile, Alabama
Phase 3: testing Sacituzumab tirumotecan for Triple Negative Breast NeoplasmsResearchers want to know if sacituzumab tirumotecan given alone or with pembrolizumab can treat triple negative breast cancer (TNBC). The main goal of this study is to learn if people treated with sacituzumab tirumotecan alone or with pembrolizumab live longer overall or without the cancer growing or spreading compared to people treated with chemotherapy.
NCT06841354 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Scottsdale, Arizona
Phase 3: testing Remibrutinib oral treatment for Relapsing Multiple SclerosisThe purpose of this Phase 3b study is to assess the how well it works, whether it is safe and how hard side effects are to live with of remibrutinib after switching from ocrelizumab and compared to continuous ocrelizumab treatment, in patients living with relapsing multiple sclerosis (plwRMS).
NCT06846281 · Official ClinicalTrials.gov record · Novartis Pharmaceuticals
RecruitingPhase 3Birmingham, Alabama
Phase 3: testing Tezepelumab for Chronic Obstructive Pulmonary Disease (COPD)A Multicenter, randomly assigned, neither you nor the study doctors know who gets the real treatment, compared with a dummy treatment, Parallel Group, Phase 3 Study to measure the how well it works and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)
NCT06878261 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Anchorage, Alaska
Phase 3: testing Trastuzumab Deruxtecan for Non-small Cell Lung CancerThis clinical trial is designed to assess the how well it works and safety of trastuzumab deruxtecan (T-DXd; Enhertu®) in combination with pembrolizumab versus platinum-based chemotherapy in combination with pembrolizumab in participants with no prior therapy for locally advanced unresectable or metastatic non-squamous NSCLC, whose tumors have HER2-overexpressing and PD-L1 TPS \<50% without known AGA that have locally available therapies targeting their AGAs in first-line advanced/metastatic setting.
NCT06899126 · Official ClinicalTrials.gov record · Daiichi Sankyo
RecruitingPhase 3Sun City, Arizona
Phase 3: testing TAR-210 for Non-Muscle Invasive Bladder NeoplasmsThe main purpose of this study is to compare the disease-free survival (the length of time after randomization that a participant survives without any signs or symptoms of the cancer returning, or progressing) between Bacillus Calmette-Guérin (BCG) treated participants receiving treatment with TAR-210 versus investigator's choice of intravesical chemotherapy for treatment of high-risk non-muscle-invasive bladder cancer (HR-NMIBC).
NCT06919965 · Official ClinicalTrials.gov record · Janssen Research & Development, LLC
RecruitingPhase 2Bakersfield, California
Phase 2: testing Tozorakimab for AsthmaThis is a dose-range finding, neither you nor the study doctors know who gets the real treatment, compared with a dummy treatment, phase IIb study designed to assess how well it works and safety of tozorakimab administered subcutaneously in adult participants with uncontrolled asthma receiving medium-to-high dose inhaled corticosteroids.
NCT06932263 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Dothan, Alabama
Phase 3: testing Mirikizumab for Ulcerative ColitisThe main purpose of this study is to show whether in these individuals, treatment with both mirikizumab and tirzepatide, compared with treatment with mirikizumab and dummy treatment (placebo), leads to decrease or disappearance of UC symptoms, and loss of at least one-tenth of the overall body weight. Participation in this study will last up to 61 weeks, including 52 weeks of treatment.
NCT06937086 · Official ClinicalTrials.gov record · Eli Lilly and Company
RecruitingPhase 3Dothan, Alabama
Phase 3: testing Mirikizumab for Crohn's DiseaseThe main purpose of this study is to measure the how well it works and safety of mirikizumab and dummy treatment (placebo) compared with mirikizumab and concomitantly administered tirzepatide in adult participants with moderately to severely active CD and obesity, or overweight. The maximum duration of this study is up to 61 weeks.
NCT06937099 · Official ClinicalTrials.gov record · Eli Lilly and Company
RecruitingPhase 3Mobile, Alabama
Phase 3: testing Pembrolizumab for Endometrial CancerResearchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent. * EC is a type of cancer that starts in the tissues inside the uterus (womb) * pMMR indicates that certain normal proteins are present in the cancer cells * Advanced means the cancer has spread locally or to other parts of the body (metastatic) and cannot be removed with surgery * Recurrent means the cancer came back after surgery Sacituzumab tirumotecan (also known as sac-TMT) and pembrolizumab are the study medicines.
NCT06952504 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Gilbert, Arizona
Phase 3: testing Sacituzumab tirumotecan for Breast NeoplasmsResearchers are looking for new ways to treat types of breast cancer that are both: * High-risk, which means the cancer may have a higher chance of getting worse or coming back after treatment * Early-stage, which means the cancer is in the breast or the lymph nodes around the breast The 2 types of breast cancer in this study are triple-negative breast cancer (TNBC) and hormone receptor (HR)-low positive/human epidermal growth factor receptor-2 (HER2) negative breast cancer. These cancers have zero or a low amount of a protein called HER2 and other proteins that attach to the hormones estrogen or progesterone.
NCT06966700 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Scottsdale, Arizona
Phase 3: testing Xanomeline/Trospium Chloride Capsule for Alzheimer DiseaseThis study wants to measure the how well it works and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease.
NCT07011732 · Official ClinicalTrials.gov record · Bristol-Myers Squibb
RecruitingNot a traditional drug phaseCalgary, Alberta
Study to Assess Change in Quality of Life of Risankizumab Treatment in Adult Participants With Moderate-to-…Psoriasis is a chronic, systemic, inflammatory disease in which skin cells build up and develop thick, red and white scaly patches on the skin. This study will assess the change in quality of life of risankizumab treatment in adult participants with moderate to severe plaque psoriasis real-world clinical practice.
NCT07039110 · Official ClinicalTrials.gov record · AbbVie
RecruitingPhase 3Daphne, Alabama
Phase 3: testing Patritumab deruxtecan for Breast NeoplasmsResearchers are looking for other ways to treat breast cancer (BC) that is hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) and either unresectable locally advanced or metastatic. * HR positive (HR+) means the cancer cells have proteins that attach to estrogen or progesterone (hormones) which help the cancer to grow and spread * HER2 negative (HER2-) means the cancer cells have a low amount of a protein called HER2 * Unresectable locally advanced means the cancer cannot be completely removed by surgery and has spread into nearby tissue or muscles * Metastatic means the cancer has spread to other parts of the body Treatment for this type of breast cancer usually includes endocrine therapy (ET) and sometimes a second treatment.
NCT07060807 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Anniston, Alabama
Phase 3: testing Vicadrostat for Diabetes Mellitus, Type 2This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure.
NCT07064473 · Official ClinicalTrials.gov record · Boehringer Ingelheim
RecruitingNot a traditional drug phaseAthens
Mechanisms of Response and Resistance to Innovative Treatments in Patients With Locally Advanced or Metasta…Ample evidence has highlighted the significant clinical benefit of novel therapies for many patients with advanced breast cancer (aBC). The use of CDK inhibitors, antibody-drug conjugates (ADCs), immune checkpoint inhibitors (ICIs), and PARP inhibitors as first-line or subsequent treatments has improved progression-free survival (PFS) rates compared to conventional therapies.
NCT07066917 · Official ClinicalTrials.gov record · Hellenic Cooperative Oncology Group
RecruitingPhase 3Phoenix, Arizona
Phase 3: testing Risankizumab for Ulcerative ColitisUlcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine). This study will assess how Risankizumab moves through the body as well as how safe and effective it is in treating pediatric participants with moderate to severely active UC.
NCT07071519 · Official ClinicalTrials.gov record · AbbVie
RecruitingPhase 2 / Phase 3Irvine, California
Phase 2 / Phase 3: testing Iza-bren for Non-Small Cell Lung CancerA Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy
NCT07100080 · Official ClinicalTrials.gov record · Bristol-Myers Squibb
RecruitingPhase 2Fort Myers, Florida
Phase 2: testing Sotorasib for Advanced Solid TumorsThe primary objective of the study is to measure the whether it is safe and how hard side effects are to live with of the continuation of sotorasib with or without panitumumab and/or other anti-cancer therapies in participants continuing to derive benefit in Amgen-sponsored protocols.
NCT07172919 · Official ClinicalTrials.gov record · Amgen
RecruitingPhase 3Anchorage, Alaska
Phase 3: testing LY4064809 for Breast NeoplasmsThe purpose of the study is to assess the how well it works and safety of the addition of Tersolisib (LY4064809/STX-478) to other anti-cancer drugs as first treatment for advanced hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Participants can remain in the study as long as the drug is helping the cancer without unbearable side effects.
NCT07174336 · Official ClinicalTrials.gov record · Eli Lilly and Company
RecruitingPhase 3Fullerton, California
Phase 3: testing Firmonertinib for Non-Small-Cell Lung CancerGlobal, Phase 3, randomly assigned, multicenter, open-label study evaluating the how well it works and safety of firmonertinib at a dose level of 240 mg QD compared to investigator's choice of osimertinib (80 mg QD) or afatinib (40 mg QD) in participants who have locally advanced or metastatic NSCLC with EGFR PACC mutations, and who have not received any prior therapy for advanced disease. you would be randomly assigned in a 1:1 ratio to treatment with firmonertinib or osimertinib or afatinib and will take the assigned dose daily.
NCT07185997 · Official ClinicalTrials.gov record · ArriVent BioPharma, Inc.
RecruitingPhase 3Birmingham, Alabama
Phase 3: testing Calderasib for Non-small Cell Lung CancerResearchers want to learn if the study medicines calderasib and subcutaneous (SC) pembrolizumab can be used to treat non-small cell lung cancer (NSCLC) when given together. Calderasib is a targeted therapy for the KRAS G12C mutation.
NCT07190248 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 2 / Phase 3Chandler, Arizona
Phase 2 / Phase 3: testing Icotrokinra for Crohn DiseaseThis study wants to evaluate how-well icotrokinra works (clinical how well it works) and how safe it is (safety) in participants with moderately to severely active Crohn's disease (CD; a long-term condition causing severe inflammation of the intestinal tract).
NCT07196722 · Official ClinicalTrials.gov record · Janssen Research & Development, LLC
RecruitingNot a traditional drug phaseMelbourne
Not a traditional drug phase: None, this is a non-interventional observational study for Alzheimer's Disease(AD)The goal of this international watch-and-measure (no experimental treatment required) study is to evaluate long-term disease outcomes and treatment safety in people with Alzheimer's disease (PwAD), by collecting real-world data from routine clinical practice across global clinical centers. The InRAD Registry watch-and-measure (no experimental treatment required) Study has several aims: * To collect medical information for many years from a large group of people with Alzheimer's disease.
NCT07213700 · Official ClinicalTrials.gov record · Stichting International Registry for Alzheimer's Disease and other Dementias Foundation
RecruitingPhase 1 / Phase 2Bakersfield, California
Phase 1 / Phase 2: testing MK-3120 for Bladder CancerResearchers are looking for new ways to treat high-risk non-muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the inside of the bladder and has not spread to the bladder muscle or outside of the bladder.
NCT07222488 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Bahía Blanca
Phase 3: testing Orforglipron for Atherosclerosis Cardiovascular DiseaseThis study wants to measure cardiovascular outcomes with orforglipron compared with dummy treatment (placebo) in participants with atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD). Participation in the study will last about 5 years.
NCT07241390 · Official ClinicalTrials.gov record · Eli Lilly and Company
RecruitingPhase 3Northridge, California
Phase 3: testing GB-0895 for Severe AsthmaThe objective of this study is to assess the potential for GB-0895 to improve the health of adolescents and adults with severe asthma that is uncontrolled by inhaled corticosteroids (ICS) and conventional asthma controllers. Additional information is available at www.SOLAIRIA.com.
NCT07276724 · Official ClinicalTrials.gov record · Generate Biomedicines
RecruitingPhase 2Phoenix, Arizona
Phase 2: testing AZD5148 for Clostridioides Difficile InfectionThis study wants to measure the how well it works and safety of AZD5148 for prevention of recurrence of Clostridioides difficile infection in Individuals 18 years of age and above.
NCT07285213 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Birmingham, Alabama
Phase 3: testing Sacituzumab tirumotecan for Ovarian NeoplasmsResearchers are looking for new ways to treat ovarian cancer (OC). Current treatment for OC may start with surgery to remove as much of the cancer as possible.
NCT07318558 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Buenos Aires
Phase 3: testing Tenecteplase for Acute Ischemic StrokeThis study is open to adults who had an acute stroke caused by a clot blocking a blood vessel in the brain (acute ischemic stroke). This study is for people who had an acute stroke or woke up with a stroke and were last seen well more than 4.5 hours before joining the study.
NCT07361302 · Official ClinicalTrials.gov record · Boehringer Ingelheim
RecruitingPhase 3Los Angeles, California
Phase 3: testing Nerandomilast for Fibrosing Interstitial Lung DiseaseThis study is open to children and adolescents aged 2 to 17 years with interstitial lung disease (ILD). Nerandomilast has just been approved in some countries to help adults with a lung condition called idiopathic pulmonary fibrosis.
NCT07366034 · Official ClinicalTrials.gov record · Boehringer Ingelheim
RecruitingPhase 3Moorpark, California
Phase 3: testing Brenipatide for Depressive Disorder, MajorThis study evaluates the safety and how well it works of brenipatide when administered with standard of care (SoC) compared to dummy treatment (placebo) plus SoC in delaying the return of major depressive symptoms. The trial is divided into four periods as follows: a screening period that will last approximately 1 month, a treatment period with a potential post treatment period that combined will last a minimum of 12 months, and the follow up period that will last approximately 2 months.
NCT07412756 · Official ClinicalTrials.gov record · Eli Lilly and Company
RecruitingPhase 2Phoenix, Arizona
Phase 2: testing LY4268989 for Ulcerative Colitis (UC)The main purpose of this study is to measure the safety and effectiveness of LY4268989 when compared to dummy treatment (placebo) in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally.
NCT07415044 · Official ClinicalTrials.gov record · Eli Lilly and Company
RecruitingPhase 3Newport Beach, California
Phase 3: testing Sacituzumab tirumotecan for Bladder CancerResearchers are looking for new ways to treat locally advanced or metastatic urothelial cancer (UC). Current treatments for locally advanced or metastatic UC include chemotherapy, immunotherapy, and targeted therapy.
NCT07419295 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Ciudad Autónoma de Buenos Aires, Buenos Aires
Phase 3: testing Calderasib for Non-small Cell Lung CancerThis is a phase 3, randomly assigned, neither you nor the study doctors know who gets the real treatment study of adjuvant calderasib plus subcutaneous pembrolizumab and berahyaluronidase alfa (MK-3475A) versus adjuvant dummy treatment (placebo) plus MK-3475a in participants with completely resected stage IIA-IIIB (N2), KRAS G12C-mutant non-small cell lung cancer following receipt of either neoadjuvant pembrolizumab plus chemotherapy or adjuvant chemotherapy. The primary goal of the study is to compare adjuvant calderasib plus MK-3475A to adjuvant dummy treatment (placebo) plus MK-3475A with respect to disease-free survival (DFS) as assessed by the investigator.
NCT07431827 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Sacramento, California
Phase 3: testing Intismeran for Non-small Cell Lung CancerResearchers are looking for new ways to treat high-risk, localized non-small cell lung cancer (NSCLC) that has been removed with surgery. People with high-risk, localized NSCLC are often treated with surgery.
NCT07513376 · Official ClinicalTrials.gov record · Merck Sharp & Dohme LLC
RecruitingPhase 3Clovis, California
Phase 3: testing Divarasib for Non-small Cell Lung CancerThe main purpose of this study is to measure the how well it works of divarasib compared with investigator's choice of immunotherapy (pembrolizumab or nivolumab) or observation in participants with resected Kirsten rat sarcoma viral oncogene homolog glycine 12 to cysteine (KRAS G12C)-positive Stage II-IIIB NSCLC, regardless of tumor programmed death-ligand 1 (PD-L1) status, who have not achieved pathologic complete response (pCR) following neoadjuvant chemoimmunotherapy.
NCT07541170 · Official ClinicalTrials.gov record · Hoffmann-La Roche
RecruitingPhase 3Duarte, California
Phase 3: testing Cevostamab for Multiple MyelomaThis study wants to assess the how well it works and safety of cevostamab in combination with pomalidomide and dexamethasone (CevosPd) versus standard of care (SOC) in participants with multiple myeloma (MM) who have received one to three prior lines of therapy and have been exposed to an anti-CD38 monoclonal antibody (mAb) and lenalidomide.
NCT07555938 · Official ClinicalTrials.gov record · Hoffmann-La Roche
RecruitingPhase 3Huntsville, Alabama
Phase 3: testing Balcinrenone/dapagliflozin for Renal Insufficiency, ChronicThis study wants to measure the how well it works, whether it is safe and how hard side effects are to live with of balcinrenone in fixed combination with dapagliflozin, compared with dapagliflozin, in patients with CKD Stage 3b and 4 (eGFR ≥ 15 to \< 45 mL/min/1.73 m2) administered orally once daily in addition to SoC. This is a population with high unmet medical need and an increased risk of CKD progression, who are frequently excluded from treatment trials.
NCT07624305 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Birmingham, Alabama
Phase 3: testing Elecoglipron for Type 2 Diabetes MellitusThis study wants to measure the how well it works, safety, and tolerability of elecoglipron alone or in combination with dapagliflozin compared with dummy treatment (placebo) in adults with type 2 diabetes mellitus (T2DM) inadequately managed with lifestyle management alone or treated with other background glucose-lowering medication.
NCT07662044 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Huntsville, Alabama
Phase 3: testing Elecoglipron for Type 2 Diabetes MellitusThis study wants to measure the how well it works, safety, and tolerability of elecoglipron and dapagliflozin in combination, compared with elecoglipron alone and dapagliflozin alone, in adults with type 2 diabetes mellitus (T2DM) inadequately managed with lifestyle management alone or treated with other background glucose-lowering medication.
NCT07662109 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Darlinghurst
Phase 3: testing Ramantamig for Multiple MyelomaThe main purpose of this study is to see how well a new treatment ramantamig-D works compared to standard treatments that is either DVRd or DRd on progression-free survival (PFS; time until a participant's disease worsens) and 12-month minimal residue disease (MRD)-negative complete response (CR) rate (percentage of participants in whom cancer cells are not detected) in participants with newly diagnosed multiple myeloma (NDMM; an initial stage of blood cancer that forms in a type of white blood cells \[WBCs\] called plasma cells) for whom stem cell transplant is not planned as initial therapy.
NCT07665450 · Official ClinicalTrials.gov record · Janssen Research & Development, LLC
RecruitingNot a traditional drug phaseAlexandroupoli
A Study in Greece Observing How Patients With Stomach and Esophageal Cancer Are Diagnosed and Treated in Ev…This is a retrospective-prospective watch-and-measure (no experimental treatment required), multicenter, single-country study aiming to describe the epidemiological characteristics and management strategies in patients with stage II-IVB gastric/GEJ adenocarcinoma in routine clinical practice in Greece.
NCT07800754 · Official ClinicalTrials.gov record · AstraZeneca
RecruitingPhase 3Tamarac, Florida
Phase 3: testing Torvutatug samrotecan for Epithelial Ovarian CancerThis study will measure the how well it works, whether it is safe and how hard side effects are to live with of Torvutatug samrotecan (torvu-sam) in combination with bevacizumab compared with bevacizumab this drug alone as first line maintenance treatment in patients with non-Homologous Recombination Deficient (non-HRD) positive advanced ovarian cancer.
NCT07851025 · Official ClinicalTrials.gov record · AstraZeneca