Endometriosis clinical trials, in English

This early phase I trial compares the side effects between patients treated with proton radiation therapy versus intensity modulated radiation therapy after surgery for the treatment of endometrial or cervical cancer. Radiation therapy uses high energy protons or x-rays to kill tumor cells and shrink tumors.

NCT04567771 · Official ClinicalTrials.gov record · Mayo Clinic

The goal of this watch-and-measure (no experimental treatment required) study is to determine the clinical validity of a deep neural network algorithm that utilizes protein biomarker detection of Endometriosis - "EndoCheck" - as an "aid in diagnosis" for endometriosis and to show validity as a diagnostic test

NCT05245695 · Official ClinicalTrials.gov record · Aspira Women's Health

Endometriosis, a chronic gynecological disorder associated with pain and infertility, is a common condition affecting approximately one in ten women. Up to 50% of patients with endometriosis have ovarian endometriomas (or "chocolate cysts").

NCT05837624 · Official ClinicalTrials.gov record · Andrew Zakhari

Collection of written consents for the study. Random assignment to groups with and without intervention.

NCT05978414 · Official ClinicalTrials.gov record · Poznan University of Physical Education

Endometriosis is a chronic incurable disease where endometrial-like tissue grows outside of the uterus, and causes symptoms such as debilitating menstrual pain, pain during intercourse, infertility, constipation, and bloating, which hurts their quality of life. Endometriosis is estimated to affect approximately 10% of women.

NCT06452407 · Official ClinicalTrials.gov record · McGill University Health Centre/Research Institute of the McGill University Health Centre

Endometriosis is an estrogen-dependent, chronic inflammatory gynecologic disease affecting women of reproductive age, with a therapeutic wandering of 6 to 10 years. A better understanding of the initiation phase is a major challenge to improve diagnosis and treatment.

NCT06502548 · Official ClinicalTrials.gov record · University Hospital, Toulouse

This study aims to measure the effects of therapy with implantable Gestrinone compared to oral Dienogest in relieving complaints related to endometriosis.

NCT06543550 · Official ClinicalTrials.gov record · Bio Meds Pharmaceutica Ltda

The central hypothesis of the investigators is that the practice of yoga will result in an improvement of endometriosis related pain symptoms for women with endometriosis.

NCT06559852 · Official ClinicalTrials.gov record · Milton S. Hershey Medical Center

The goal of this randomly assigned controlled trial is to assess whether a 12-week anti-inflammatory diet can improve fertility outcomes in women with endometriosis undergoing In Vitro Fertilization (IVF). The main questions are: * Does the anti-inflammatory diet reduce the rate of inadequate ovarian response to hormonal stimulation (retrieval of ≤3 oocytes)?

NCT06885125 · Official ClinicalTrials.gov record · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

The aim of the study is to test the effect of tDCS stimulation on upper and lower limb function in neurological patients and to reduce pain in gynaecological patients. And the impact of tDCS stimulation on patients' quality of life.

NCT06891690 · Official ClinicalTrials.gov record · Poznan University of Physical Education

The goal of this clinical trial is to evaluate whether ultrasound-guided alcohol sclerotherapy can improve pelvic pain and quality of life in women aged 18 to 45 diagnosed with ovarian endometriomas, compared to expectant management. The main questions it aims to answer are: 1.

NCT06955221 · Official ClinicalTrials.gov record · Hospital Universitari de Bellvitge

Endometriosis surgery is required when medical treatment fails to release women from pain. However, complete surgery does not work every time to improve patients' symptoms.

NCT06997809 · Official ClinicalTrials.gov record · University Hospital, Limoges

The study is a prospective, monocentric, randomly assigned controlled, two-armed, pilot-study conducted at Department for Women's Health, Tuebingen, Germany. In this Post Market Study it will be determined whether and to what extent the two surgical procedures for ovarian endometrioma treatment (standard cystectomy versus APC) may affect the ovarian reserve by comparing changes in serum AMH levels after treatment.

NCT07065214 · Official ClinicalTrials.gov record · Erbe Elektromedizin GmbH

There is increasing evidence that examining our eyes can tell us a lot of information about our health, and systemic diseases. Our plan is to compare the images taken of the back of eyes of women who have endometriosis with those of women who don't.

NCT07232485 · Official ClinicalTrials.gov record · University of Edinburgh

A phase 3 study to measure the how well it works and safety of HMI-115 in women with moderate to severe endometriosis-associated pain over a 24-week treatment period and a 28-week extension

NCT07318688 · Official ClinicalTrials.gov record · Hope Medicine (Nanjing) Co., Ltd

This study examines whether the food supplement Doliral can improve quality of life and reduce pelvic pain in women with endometriosis, compared with dummy treatment (placebo), over several weeks.

NCT07393958 · Official ClinicalTrials.gov record · Arafarma Group, S.A.

The goal of this study/research is to assess the relationship between ultrasound features of the myometrium suggestive of adenomyosis and clinical symptoms of adenomyosis and to establish a reporting system for adenomyosis assessing disease severity. Consecutive pre- and perimenopausal symptomatic and asymptomicasymptomatic women with an uterus presenting for gynaecological ultrasound exams will be asked to participate in the study.

NCT07397715 · Official ClinicalTrials.gov record · Swiss GO Trial Group

Telehealth, or telemedicine, utilizes technology to deliver clinical care remotely, either in real time or asynchronously, between clinician and patient. Telemedicine has been successfully implemented to increase healthcare delivery for patients in rural areas with otherwise long travel times, and studies have also determined that telemedicine can increase patient satisfaction scores while simultaneously decreasing direct and indirect costs for patients.

NCT07420114 · Official ClinicalTrials.gov record · University of Chicago

Adult patients consulting the gynecological emergency department of CHI Créteil during the inclusion period for endometriosis or symptoms suggestive of endometriosis

NCT07472842 · Official ClinicalTrials.gov record · Centre Hospitalier Intercommunal Creteil

We will conduct this study to estimate the effect of laparoscopic cystectomy on ovarian reserve in endometriotic cysts versus non-endometriotic cysts.

NCT07686783 · Official ClinicalTrials.gov record · Benha University

Endometriosis is a condition in which tissue similar to the lining of the uterus grows outside the uterus, often causing pain and infertility. Currently, endometriosis can only be definitively diagnosed through invasive procedures like laparoscopy and biopsy.

NCT07713797 · Official ClinicalTrials.gov record · Trio Fertility

This is a phase II, two-arm, noncomparative screening study of Sacituzumab tirumotecan, an intravenous antibody-drug conjugate (ADC) that targets Trop-1, administered alone or in combination with pembrolizumab, a monoclonal antibody to PD-1 in patients with relapsed clear cell cancers that originated in the ovary, fallopian tube or peritoneal cavity, inclusive of endometriosis (collectively referred to as OCCC throughout the protocol) after previous treatment with anti-PD1 therapy. The regimens will be evaluated separately, and the study is not designed or powered to compare the regimens.

NCT07718854 · Official ClinicalTrials.gov record · Tufts Medical Center

Endometriosis is a chronic condition that may cause pelvic pain, ovarian cysts, infertility, and recurrent symptoms. This prospective watch-and-measure (no experimental treatment required) cohort study will enroll women aged 18 to 45 years with endometriosis and age- and body mass index-matched healthy women.

NCT07749053 · Official ClinicalTrials.gov record · Li Li

The goal of this clinical trial is to find out how the study drug HHK001 compares to Enantone (an approved treatment for endometriosis) when given as a single 3.75 mg injection to participants with endometriosis. Both products contain the same active ingredient: leuprorelin acetate.

NCT07755956 · Official ClinicalTrials.gov record · Zhuhai Huahaikang Pharmaceutical Technology Co., Ltd.

Endometriosis is a chronic estrogen-dependent disease characterized by the presence and growth of endometrium-like tissue outside the uterine cavity. This ectopic endometrial tissue induces a chronic local and systemic inflammatory response, resulting in the most common manifestations of the disease: chronic pelvic pain, infertility, and pelvic adhesions.

NCT07776574 · Official ClinicalTrials.gov record · Charles University, Czech Republic

WorkoutCPP is a pilot study evaluating the feasibility of a personalized exercise recommendation system for individuals with chronic pelvic pain disorders (CPPDs). The study uses reinforcement learning (RL), a type of artificial intelligence that adapts recommendations over time based on each participant's reported pain levels, symptom burden, and exercise compliance.

NCT07810218 · Official ClinicalTrials.gov record · Icahn School of Medicine at Mount Sinai

The goal of this watch-and-measure (no experimental treatment required) study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired endometrial receptivity in women aged 18-45 years. The main questions it aims to answer are: Can AI algorithms, applied to standardized transvaginal ultrasound images, accurately detect and classify endometriosis and adenomyosis in real time during routine examination?

NCT07810920 · Official ClinicalTrials.gov record · Semmelweis University

This study hypothesizes that the histological, immunophenotypic, and molecular characterization of atypical endometriotic lesions may be related to specific clinical and ultrasound features.Identifying potentially atypical lesions would allow for more accurate stratification of patients, distinguishing definitely benign from potentially atypical endometriosis. The targeted study of endometriosis, both typical and atypical, also with reference to the inflammatory microenvironment, as well as immunophenotypic and molecular characteristics, could allow the formulation of pathogenic hypotheses on the development and progression of atypia towards malignant neoplasms.

NCT07816133 · Official ClinicalTrials.gov record · Casa di Cura Dott. Pederzoli

Study Objectives This study aims to investigate the effects of preoperative stellate ganglion block and intraoperative intravenous dexmedetomidine on postoperative sleep disturbance in patients undergoing laparoscopic gynecologic surgery, with the goals of reducing pain and postoperative adverse reactions and identifying an effective, safe, economical, and broadly applicable intervention strategy that may facilitate emergence from anesthesia, accelerate postoperative recovery, shorten the length of hospital stay, and reduce hospitalization costs. This trial aims to determine whether preoperative stellate ganglion block (SGB) and intraoperative intravenous dexmedetomidine (DEX) can improve postoperative sleep quality in patients undergoing laparoscopic gynecologic surgery, and whether the combination of these two interventions provides an interaction effect or additional ben

NCT07860203 · Official ClinicalTrials.gov record · Catherin Zhang

This retrospective monocentric study aims to assess the feasibility and clinical relevance of three-dimensional (3D) modeling of deep endometriosis lesions derived from pelvic MRI. The study evaluates whether 3D reconstruction improves surgical planning and multidisciplinary management.

NCT07864883 · Official ClinicalTrials.gov record · University Hospital, Strasbourg, France

This study is a neither you nor the study doctors know who gets the real treatment, randomly assigned, compared with a dummy treatment study that evaluates the whether it is safe and how hard side effects are to live with of a fiber-based dietary supplement and the mechanistic and structure-function effects of that supplement on the gut and vaginal microbiome, gastrointestinal well-being, and quality-of-life parameters in 140 women with endometriosis and co-existing gastrointestinal symptoms over 12 weeks. The primary objective is to measure the whether it is safe and how hard side effects are to live with of the supplement, measured by the incidence and severity of gastrointestinal side effects (AEs) and discontinuations.

NCT07875062 · Official ClinicalTrials.gov record · LOAM Science

The goal of this clinical trial is to learn whether \[18F\]AlF-FAPI-74 PET/CT can help detect endometriosis in adult women who are already scheduled for laparoscopy due to suspicion of deep infiltrating endometriosis or superficial peritoneal endometriosis. The main aims are: (i) How well does \[18F\]AlF-FAPI-74 PET/CT identify endometriosis lesions compared with findings during laparoscopy?

NCT07876648 · Official ClinicalTrials.gov record · Universitaire Ziekenhuizen KU Leuven

The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors. Although surgery is an integral part of treatment, a significant proportion of patients experience persistent pain several months after the procedure.

NCT07882498 · Official ClinicalTrials.gov record · Centre Hospitalier Universitaire, Amiens